Comparative study of Curiementor ionization chambers using Monte Carlo simulations.
Identifieur interne : 001A73 ( Main/Exploration ); précédent : 001A72; suivant : 001A74Comparative study of Curiementor ionization chambers using Monte Carlo simulations.
Auteurs : RBID : pubmed:20133143English descriptors
- KwdEn :
- Barium Radioisotopes, Brachytherapy (instrumentation), Calibration, Cesium Radioisotopes, Cobalt Radioisotopes, Computer Simulation, Equipment Design, Fluorine Radioisotopes, Gallium Radioisotopes, Humans, Indium Radioisotopes, Iodine Radioisotopes, Monte Carlo Method, Radiometry (instrumentation), Radiopharmaceuticals (administration & dosage), Reference Standards, Sensitivity and Specificity, Technetium.
- MESH :
- chemical , administration & dosage : Radiopharmaceuticals.
- chemical : Barium Radioisotopes, Cesium Radioisotopes, Cobalt Radioisotopes, Fluorine Radioisotopes, Gallium Radioisotopes, Indium Radioisotopes, Iodine Radioisotopes, Technetium.
- instrumentation : Brachytherapy, Radiometry.
- Calibration, Computer Simulation, Equipment Design, Humans, Monte Carlo Method, Reference Standards, Sensitivity and Specificity.
Abstract
Ionization chambers (ICs) are the most commonly used instrument for measuring activities of solutions containing radiopharmaceuticals used in nuclear medicine, due to their simplicity of operation and accurate measurement results. As the dose delivered to the patient is determined by these measurements, for optimal results, the activity of these radiopharmaceuticals must be determined as accurately as possible, so that the radioprotection requirements are accomplished and at the same time good therapy or imaging results are achieved. In this work, the response of the ionization chamber Curiementor 2, from PTW-Freiburg, was studied by simulation with Monte Carlo (MC) code MCNPX and compared with experimental results for several radionuclides. The good agreement between experimental and simulation results validates the used methodology. The energy dependent sensitivity function, S (E), was established. Several ionization chambers were studied for (18)F and (99m)Tc, through Monte Carlo simulation method. In particular, some alterations to the original design of the Curiementor 2 were analysed, as well as the geometry of more recent chambers developed by PTW, namely Curiementor 3 and PET Curiementor 4. Calibration coefficients were compared for sources at different positions. Importance volumes were defined and determined for the Curiementors 2 and 3 and its ratio related with the corresponding ratio of sensitivity functions.
DOI: 10.1016/j.apradiso.2009.12.040
PubMed: 20133143
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative study of Curiementor ionization chambers using Monte Carlo simulations.</title><author><name sortKey="Sim Es, Catarina" uniqKey="Sim Es C">Catarina Simões</name><affiliation wicri:level="1"><nlm:affiliation>Instituto Tecnológico e Nuclear, Estrada Nacional 10, 2686-953 Sacavém, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Instituto Tecnológico e Nuclear, Estrada Nacional 10, 2686-953 Sacavém</wicri:regionArea></affiliation></author><author><name sortKey="Caldeira, Margarida" uniqKey="Caldeira M">Margarida Caldeira</name></author><author><name sortKey="Oliveira, Carlos" uniqKey="Oliveira C">Carlos Oliveira</name></author></titleStmt><publicationStmt><date when="2010">2010</date><idno type="doi">10.1016/j.apradiso.2009.12.040</idno><idno type="RBID">pubmed:20133143</idno><idno type="pmid">20133143</idno><idno type="wicri:Area/Main/Corpus">001A96</idno><idno type="wicri:Area/Main/Curation">001A96</idno><idno type="wicri:Area/Main/Exploration">001A73</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Barium Radioisotopes</term><term>Brachytherapy (instrumentation)</term><term>Calibration</term><term>Cesium Radioisotopes</term><term>Cobalt Radioisotopes</term><term>Computer Simulation</term><term>Equipment Design</term><term>Fluorine Radioisotopes</term><term>Gallium Radioisotopes</term><term>Humans</term><term>Indium Radioisotopes</term><term>Iodine Radioisotopes</term><term>Monte Carlo Method</term><term>Radiometry (instrumentation)</term><term>Radiopharmaceuticals (administration & dosage)</term><term>Reference Standards</term><term>Sensitivity and Specificity</term><term>Technetium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Barium Radioisotopes</term><term>Cesium Radioisotopes</term><term>Cobalt Radioisotopes</term><term>Fluorine Radioisotopes</term><term>Gallium Radioisotopes</term><term>Indium Radioisotopes</term><term>Iodine Radioisotopes</term><term>Technetium</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Brachytherapy</term><term>Radiometry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Calibration</term><term>Computer Simulation</term><term>Equipment Design</term><term>Humans</term><term>Monte Carlo Method</term><term>Reference Standards</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ionization chambers (ICs) are the most commonly used instrument for measuring activities of solutions containing radiopharmaceuticals used in nuclear medicine, due to their simplicity of operation and accurate measurement results. As the dose delivered to the patient is determined by these measurements, for optimal results, the activity of these radiopharmaceuticals must be determined as accurately as possible, so that the radioprotection requirements are accomplished and at the same time good therapy or imaging results are achieved. In this work, the response of the ionization chamber Curiementor 2, from PTW-Freiburg, was studied by simulation with Monte Carlo (MC) code MCNPX and compared with experimental results for several radionuclides. The good agreement between experimental and simulation results validates the used methodology. The energy dependent sensitivity function, S (E), was established. Several ionization chambers were studied for (18)F and (99m)Tc, through Monte Carlo simulation method. In particular, some alterations to the original design of the Curiementor 2 were analysed, as well as the geometry of more recent chambers developed by PTW, namely Curiementor 3 and PET Curiementor 4. Calibration coefficients were compared for sources at different positions. Importance volumes were defined and determined for the Curiementors 2 and 3 and its ratio related with the corresponding ratio of sensitivity functions.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20133143</PMID><DateCreated><Year>2010</Year><Month>03</Month><Day>15</Day></DateCreated><DateCompleted><Year>2010</Year><Month>06</Month><Day>24</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9800</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><Issue>6</Issue><PubDate><Year>2010</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine</Title><ISOAbbreviation>Appl Radiat Isot</ISOAbbreviation></Journal><ArticleTitle>Comparative study of Curiementor ionization chambers using Monte Carlo simulations.</ArticleTitle><Pagination><MedlinePgn>1121-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.apradiso.2009.12.040</ELocationID><Abstract><AbstractText>Ionization chambers (ICs) are the most commonly used instrument for measuring activities of solutions containing radiopharmaceuticals used in nuclear medicine, due to their simplicity of operation and accurate measurement results. As the dose delivered to the patient is determined by these measurements, for optimal results, the activity of these radiopharmaceuticals must be determined as accurately as possible, so that the radioprotection requirements are accomplished and at the same time good therapy or imaging results are achieved. In this work, the response of the ionization chamber Curiementor 2, from PTW-Freiburg, was studied by simulation with Monte Carlo (MC) code MCNPX and compared with experimental results for several radionuclides. The good agreement between experimental and simulation results validates the used methodology. The energy dependent sensitivity function, S (E), was established. Several ionization chambers were studied for (18)F and (99m)Tc, through Monte Carlo simulation method. In particular, some alterations to the original design of the Curiementor 2 were analysed, as well as the geometry of more recent chambers developed by PTW, namely Curiementor 3 and PET Curiementor 4. Calibration coefficients were compared for sources at different positions. Importance volumes were defined and determined for the Curiementors 2 and 3 and its ratio related with the corresponding ratio of sensitivity functions.</AbstractText><CopyrightInformation>Copyright 2010 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Simões</LastName><ForeName>Catarina</ForeName><Initials>C</Initials><Affiliation>Instituto Tecnológico e Nuclear, Estrada Nacional 10, 2686-953 Sacavém, Portugal.</Affiliation></Author><Author ValidYN="Y"><LastName>Caldeira</LastName><ForeName>Margarida</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Oliveira</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>01</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Appl Radiat Isot</MedlineTA><NlmUniqueID>9306253</NlmUniqueID><ISSNLinking>0969-8043</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Barium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Cesium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Cobalt Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Fluorine Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Gallium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Iodine Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-26-8</RegistryNumber><NameOfSubstance>Technetium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Barium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Brachytherapy</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Calibration</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cesium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cobalt Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Equipment Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Fluorine Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gallium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Iodine Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Monte Carlo Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiometry</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Reference Standards</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Technetium</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>7</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2009</Year><Month>12</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2009</Year><Month>12</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2010</Year><Month>1</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>6</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0969-8043(09)00824-0</ArticleId><ArticleId IdType="doi">10.1016/j.apradiso.2009.12.040</ArticleId><ArticleId IdType="pubmed">20133143</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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